A Comparison of Long-Acting Injectable Medications for Schizophrenia (ACLAIMS)
25
360
Randomized, double-masked comparative effectiveness clinical trial
2009
2014
Columbia Univ, NIMH
Accelerating COVID-19 Therapeutic Interventions and Vaccines, The ACTIV-1 Immune Modulator (IM); Immune Modulators for Treating COVID-19 (ACTIV-1 IM) (ACTIV-1 IM )
85
1,971
Interventional
2020
2022
US Department of Health and Human Services
Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN )
2017
2021
Aging and Cognitive Health Evaluation in Elders (ACHIEVE )
4
977
Treatment
2018
2023
NIA
ARIC Carotid MRI (CARMRI)
4
2,066
Cross-sectional and prospective design
2004
2009
NHLBI
ARIC MRI and Neurocognitive Longitudinal Study (ARIC MRI)
2
1,134
Prospective cohort follow-up
2002
2008
NHLBI
ARIC Neurocognitive Study (ARIC-NCS )
4
8,600
Observational study
2010
2019
NHLBI
Asymptomatic Carotid Atherosclerosis Study (ACAS)
37
1,500
Randomized, unmasked trial
1987
1998
Atherosclerosis Risk in Communities (ARIC )
4
15,792
Prospective cohort follow-up
1985
2028
NHLBI
Back Pain Consortium Research Program (BACPAC )
2019
2024
NIAMS
Biomarkers for Evaluating Spine Treatment (BEST )
12
1,014
Sequential Multiple Assignment Randomized Trial (SMART)
2022
2024
NIAMS
Bronchiectasis Research Registry (BRON)
11
Patient Registry
2007
2014
COPD Foundation
Cholesterol Reduction in Seniors Program (CRISP)
5
400
Randomized, double-masked pilot study
1990
1992
NHLBI
Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed with Crohn's Disease (CAMEO )
26
900
Interventional
2023
2028
NIDDK
Combining Medications and Behavioral Interventions (COMBINE)
11
1,380
Randomized 2x2x2 factorial trial
1997
2007
NIAAA
Comparison of Antipsychotics for Metabolic Problems (CAMP)
26
300
Randomized, open-label placebo-controlled clinical trial
2006
2011
NHLBI
Comparison of Depression Interventions after Acute Coronary Syndrome (CODIACS)
5
150
Randomized, single-masked clinical trial
2009
2011
NHLBI
Comparison of Optimal Antipsychotic Treatments for Schizophrenia (COATS)
15
90
Randomized, open-label clinical trial
2008
2011
NIMH
Dietary Effects on Lipoproteins and Thrombogenic Activity (DELTA, DELTA-1, DELTA-2)
4
103, 85
2 Randomized, double-masked trials
1992
1996
NHLBI
Enhancing Recovery in Coronary Heart Disease (ENRICHD)
8
2,481
Randomized, unmasked trial
1995
2005
NHLBI
Epidemiologic Studies of Glargine Use and Cancer Risk (DIMS-ESGUCR )
Multi-site retropspective study
2009
2013
Sanofi-Aventis
Extremely Low Gestational Age Newborns (ELGAN)
12
8,000
Observational Study
2016
2018
NICHD
Fluvastatin Registration Program (FRP)
68
2,000
7 Randomized, double-masked trials, open-label safety study
1988
1991
Hispanic Community Health Study / Study of Latinos (HCHS-SOL )
4
16,000
Population-based prospective cohort follow-up
2006
2019
NHLBI
Hispanic Community Health Study / Study of Latinos Youth Study (HCHS-SOLY)
4
1,600
Cross-sectional observational study
2011
2014
NHLBI
International Studies of CVD (INTL)
7
20,000
4 prospective cohort follow-up, randomized, unmasked trials
1990
2000
NHLBI
Jackson Heart Study Advisory Coordinating Center (JHS)
1
6,500
Prospective cohort follow-up, family genetic study
1999
2018
NHLBI
Laser Induced, Biologically Engineered Remodeling of Thermally Injured Skin Trial (LIBERTI)
2013
2017
Lipid Research Clinics Program (LRC)
16
116,800
Prevalence Study, Prospective cohort follow-up, Randomized, double-masked trial, Family genetics study
1971
1990
NHLBI
Longitudinal Studies of Child Abuse and Neglect (LONGSCAN)
5
1,400
Prospective cohort follow-up
1991
2011
NCCAN
Maternal Oral Therapy to Reduce Obstetric Risk (MOTOR )
3
1,800
Randomized, unmasked trial
2003
2009
NIDCR
Medical Optimization of Management of Type 2 Diabetes Complicating Pregnancy (MOMPOD )
9
1,200
Randomized double masked placebo controlled clinical trial
2016
2021
NICHD
Metformin in Treatment of Antipsychotic-Induced Weight Gain in Schizophrenia (METS)
17
80
Randomized, double-masked placebo-controlled trial
2008
2010
NIMH
MOTOR Kids (MOTORKIDS)
3
332
Observational study
2006
2011
NIDCR
National Strategy for Environment and Health, United Arab Emirates (UAEE)
600
Population survey
2008
2012
Environmental Agency - Abu Dhabi
Obesity Prevention in Native American Indians (PATHWAYS)
4
1,700
Community randomized, single-masked trial
1993
2004
NHLBI
Periodontal treatment to Eliminate Minority Inequality and Rural disparities in Stroke (PREMIERS)
0
0
2015
2019
Periodontitis and Vascular Events (PAVE)
5
3,000
Randomized pilot study
2001
2006
University of Buffalo
Precision Interventions for Severe and/or Exacerbation-Prone Asthma Network (PrecISE )
10
800
Clinical Trial
2018
2023
NHLBI
Predicting Responses to Standardized Pediatric Colitis Therapy (PROTECT)
24
430
Multicenter open-label clinical trial
2012
2017
Univ Connecticut, NIDDK
Randomized Intervention in Children with VesicoUreteral Reflux (RIVUR)
15
600
Randomized, double-masked controlled clinical trial
2005
2015
NIDDK
SPIROMICS Study of Early COPD Progression (SOURCE )
14
1,000
Observational
2021
2025
NHLBI, COPD Foundation
Studies of Left Ventricular Dysfunction (SOLVD)
28
6,300
2 Randomized, double-masked trials
1985
1993
NHLBI
Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS )
12
3,200
Observational study
2009
2022
NHLBI and COPD Foundation
Telehealth-Enhanced Assessment and Management after Stroke - Blood Pressure (TEAMS-BP )
12
1,550
multi-site, parallel, 2-arm RCT trial with 1-to-1 allocation to treatment and randomization is stratified by site and rac
2024
2028
PCORI
The Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure with Preserved Ejection Fraction (SPIRRIT-HFpEF )
78
2,400
Interventional
2017
2026
The Swedish Heart-Lung Foundation, The Swedish Research Council, The Erling Persson Foundation, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), National Institutes of Health Center for Advancing Translational Science (NCATS)
Trial of Activity for Adolescent Girls (TAAG)
6
10,000
2-arm group randomized trial
2000
2009
NHLBI
Trial of Surgery & Thrombolysis in Ischemia of the Lower Extremity (STILE)
34
400
Randomized, unmasked trial
1991
1994
NHLBI
Trial to Assess Chelation Therapy 2 (TACT2 )
88
1,000
Interventional
2021
2023
The National Center for Complementary and Integrative Health, The National Heart, Lung, and Blood Institute, The National Institute for Diabetes Digestive and Kidney Diseases, The National Institute of Environmental Health Sciences (NIEHS)
Vitamin Intervention for Stroke Prevention (VISP)
56
3,600
Randomized, double-masked trial
1996
2008
NHLBI
Women's Health Initiative (WHI )
4,700
Observational study and clinical trials
2011
2021
Fred Hutchinson Cancer Inst., NHLBI