The San Diego field site is a partnership between San Diego State University Graduate School of Public Health (SDSU), University of California at San Diego School of Medicine (Preventive Cardiology) (UCSD), and the San Ysidro Health Center (SYHC). Primary functions and responsibilities play on the expertise of each partner. SDSU staff’s primary functions include recruitment and retention of the study population, psychosocial and behavioral theory development and measurement, training core activities, the hearing exams, the cognitive status assessments, physical activity assessment, and formative research and community consultation. UCSD staff’s primary functions include the CVD risk factors, subclinical disease and CVD events ascertainment, sleep studies, medical records adjudication, and oversight for pulmonary function test.

SYHC, as a partner, provides expertise regarding health promotion and research in the Hispanic/Latino community, and ambulatory and hospital services for the Hispanic/Latino community. The primary service area of SYHC is South Suburban and Central San Diego County, or the "South Bay". SYHC has 4 medical clinics extending along the corridor from the border to National City. The fact that SYHC is present in the South Suburban and Central region facilitates their role in the partnership in terms of community consultation, established contacts with the medical community, and the potential to assist with recruitment and access to care for potential participants.

SYHC staff’s primary functions include outreach efforts in the target community, formative research and community consultation, recruitment, access to care for uninsured patients, health education, dental exams, and the training core activities. In particular, SYHC plays a central role in giving back to the target community. SYHC is responsible for the health education component of the HCHS/SOL. SYHC hires, trains and supervises several promotores or lay health advisors, who provide participants with risk factor counseling and referral into SYHC and/or other community programs.

The San Diego field site is located in the heart of the target area in the city of Chula Vista between Interstate 5 and 805. The site is accessible by bus, a light rail system and there is ample parking for those that drive. The clinical space occupies 3,600 square feet in commercial medical office space on the campus of the Scripps Chula Vista Hospital. The suite has about 20 rooms to comfortably accommodate participants during the screening process including adult and child waiting areas and staff offices with views of San Diego Bay.