The Miami Field Center represents a university-wide collaboration involving the College of Arts and Sciences and the Miller School of Medicine of the University of Miami (UM) together with multiple community partners including community-based primary care practices affiliated with Jackson Memorial Hospital / University of Miami (JMH/UM) , community-services agencies, the Miami-Dade County Health Department (MDCHD), and a Community Advisory Board. Within this context, the University of Miami provides expertise for the administration of all required questionnaires as well as components of medical examinations, recruitment, and follow-up activities. The Miami HCHS/SOL Community Advisory Coalition, which is an alliance of individuals and community organizations, supports the recruitment, retention, and health education efforts of the Miami Field Center and provides advice and guidance regarding potentially relevant relationships among the community, study participants, and the HCHS/SOL.

Administration of questionnaires, interviews, and most examination procedures are conducted in the Clinical Research Building (CRB) of the University of Miami/Jackson Memorial Medical Center in the city of Miami. More than 600,000 Hispanics/Latinos live within 7 miles of the CRB. Adequate parking is available on site and the CRB is in close proximity to public transportation including an elevated train, buses, and taxis. The fifteen story building is dedicated to research 7 days a week with 24-hour security. During regular working hours the service/reception area is staffed by the University to greet, orient, and direct participants within the strict guidelines of privacy prescribed for clinical research protocols. At other times, as necessary, the service/reception area for the HCHS/SOL is staffed by the Miami Field Center.

The CRB provides research office space as well as clinical examination and laboratory space. All investigators and staff for the Miami Field Center have assigned office space in the CRB. The clinical space for the HCHS/SOL is located on the 6th floor of the CRB, within the Behavioral Medicine Research Center. This includes 10 dedicated rooms specifically designed for HCHS/SOL interactions with participants. Facilities are appropriate for blood draws, sample preparation, oral glucose tolerance tests (OGTT), etc. Storage facilities for refrigeration, ultra-low temperature (-70oC) freezers, and centrifugation are all conveniently available within the Behavioral Medicine Research Center as are facilities for data management, equipment maintenance (e.g., for sleep studies), etc.