The Department of Preventive Medicine at Northwestern University (NU), Feinberg School of Medicine in collaboration with the Midwest Latino Health Research Training & Policy Center at the University of Illinois at Chicago (UIC) established The Chicago Hispanic Community Health Study Field Center (CFC). The CFC utilizes collaborative resources of Hispanic/Latino and other investigators at Northwestern University, University of Illinois at Chicago, Roosevelt University, Kennedy King College, and participating community based organizations/media to identify, recruit, and screen possible participants and to retain participants for annual follow-up studies.

The clinical examinations for the HCHS/SOL are performed at two locations. The primary site is a community clinic known locally as the Community Health Clinic or simply, CommunityHealth, which is a volunteer-based organization dedicated to enhancing the health and wellness of the underserved Chicago community by providing free services to uninsured individuals (approximately 65% of Hispanic/Latino origin) without sufficient financial means. The clinic is affiliated with both NU and UIC through the medical training program. It serves the metropolitan Chicago area and beyond, with the majority of patients coming from Humboldt Park, West Town, Logan Square, and the Near North Side.

The clinic offers 15 examining rooms, a laboratory, three bathrooms, a kitchen, a large conference room, and reception area with children's play area. Usually the clinic opens for patient services later in the day and closes between 9 and 10pm. In order for staff to collect the baseline examination, the clinic hours start early in the morning and continue into early afternoon. The clinic is located on a business street in a primarily residential area on the near-northwest side; street parking is readily available and the clinic is directly accessible via public transportation.

The secondary site is the Department of Preventive Medicine's Research Clinic (DPMRC). The DPMRC is located in rented space on the 8th floor of the building which houses the department offices adjacent to Northwestern's downtown campus. The DPMRC is utilized by several ongoing studies including CARDIA, MESA, the Chicago Healthy Aging Study, and WHI. The clinic offers 5 examining rooms, a laboratory, 2 bathrooms, a kitchen, a conference room, and a reception area.