This program generates Simon's optimal two-stage designs (Simon, 1989) and admissible designs from Jung et al. (2004) for Phase II single arm clincial trials.

1. Simon R (1989). Controlled Clinical Trials 10: 1-10. Click here to download Simon's (1989) article.
2. Jung SH, Lee TY, Kim KM, George S (2004). Admissible two-stage designs for phase II cancer clinical trials, Statistics in Medicine 23: 561-569.
Type I error rate, α (one-sided):
Power:
Response probability of poor drug, p0:
Response probability of good drug, p1: