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    The Atherosclerosis Risk in Communities Study Neurocognitive Study
, will estimate variation in the burden of dementia and mild cognitive impairment by race and sex and investigate the role of midlife vascular risk factors in predicting dementia (including Alzheimer's Disease) and cognitive decline. The study aims to elucidate factors underlying ethnic disparities in dementia burden and provide the scientific basis for prevention strategies by identifying vascular therapeutic targets, optimal timing for interventions and useful intermediate outcomes. The study will add neurocognitive testing and brain imaging to a planned re-examination of ARIC cohort participants between 2011 and 2013. Over the past 20 years, the ARIC study has collected data on an initial cohort of 15,792 middle age African-American and white men and women to investigate risk factors for diseases and factors including heart disease, hypertension and cognitive function. Using the data from this study and the wealth of information already collected in ARIC, we expect to find out more about the causes of dementia and less severe symptoms of mild cognitive impairment.